 | Author(s) | | | Seidl S, Kaufmann and Drach J |
| Publication | | | The Lancet Oncology |
| Reference | | | Vol 4 |
| Publication Date | | | September 2003 |
|  |  Relevant to nurses in haematology to inform knowledge of the Pathophysiology of the disease.
This is an in depth review of multiple myeloma, which takes the reader from normal B cell development, through the malignant changes which take place in myeloma.
Cytogenetics are considered discussing the characteristic chromosomal abnormalities, the authors also consider oncogenic events including the mutation of p53 and the role of cytokines. Bone lesions are explained and therapies mentioned.
Although this is an in depth review it can be utilised as a reference tool to be read in its entirety or selected sections.
Comment by: Tracey Burgoyne, Lecturer/Practitioner Cancer Care, University of Central England, 2004.
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